The best road trip stops on the Houston to Biloxi drive are Beaumont TX, Lafayette LA and Baton Rouge. The distance from Houston to Biloxi is 414 miles, with a 5h54m driving time.
Planning a Houston to Biloxi road trip itinerary
The Houston to Biloxi drive takes you from the biggest city in Texas to the Mississippi coast.
Five great things to do in Houston
- 🚀 Reserve your tickets – for Houston’s number one attraction, Space Center Houston.
- 🎵 Discover Houston’s hip-hop culture – on a motorised party bike.
- 🚇 Explore the largest downtown tunnel system in the US – on the Astroville Tunnel Tour.
- 🎨 On a downtown mural tour – learn about Houston’s street art scene.
- 🖼️ Immerse yourself in a spectacular interactive art installation – at Meow Wolf’s Radio Tave.
The top Houston attraction is unquestionably the Space Center Houston, which takes you behind the scenes of the Johnson Space Center. This includes the Mission Briefing Center, and a vast array of high tech exhibitions.
Other attractions include the Houston Museum of Natural Science, Downtown Aquarium, Museum of Fine Arts Houston and Children’s Museum.
For more Houston experiences, try hip hop party bike tours, foodie walks in the Montrose neighbourhood and quirky tours of Houston’s tunnel system.
Top Houston accommodation options include the superb value Club Quarters Houston Downtown and the upscale but boutique Magnolia.
Biloxi on the Mississippi coast is best known as a casino destination, but there’s plenty to keep non-gamblers interested. The Biloxi Lighthouse opened in 1848, and is now open for public tours. The Maritime and Seafood Industry Museum covers the region’s history, and looks at just how big a business fishing is. You can also take a cruise on one of the schooners moored outside the museum.
Also in Biloxi is Beauvoir, the lavish home of Confederate president Jefferson Davis. The mansion is open for tours.
For Biloxi accommodation, try the Scarlet Pearl Casino Resort for entertainment and the South Beach Hotel and Suites for beachside location.
Houston to Biloxi distance and driving time
By car, the distance from Houston to Biloxi is 414 miles. That makes for a driving time of around five hours and 54 minutes. The quickest route is along the I-10.
The best stops to add to a Houston to Biloxi road trip itinerary are Beaumont TX, Lafayette LA and Baton Rouge.
Things to do on the Houston to Biloxi drive: Beaumont TX
Beaumont TX is just west of the Louisiana border. The top attraction is the Spindletop Boomtown Museum, located on the site of a 1901 oil strike that changed West Texas forever. It’s a recreated town, with rebuilt historic buildings, and plenty of Texas oil history.
Also worth looking at is the McFaddin-Ward House Museum, a heritage home with original art and furnishings. It gives a good idea of how much money was sloshing around in the early 20th century.
Houston to Biloxi road trip attractions: Lafayette LA
Lafayette’s top attractions include Acadian Village, a recreated 19th-century Cajun village, which plays host to artisans and craftspeople among the historic homes.
Vermilionville is similar, but the living history museum here looks at the cultures of Native American and Creole people as well as the Acadians.
Elsewhere, the Cathedral of St John the Evangelist is famed for its stained glass windows.
Top Lafayette experiences include Cajun food tours and Cajun cultural and history tours.
Best stops between Houston and Biloxi: Baton Rouge
The obvious attraction in Baton Rouge is the Louisiana Capitol Building, but the castle-like Old Capitol Building is more attractive. It’s also now a museum, with interactive exhibits on democracy and the colourful characters who have walked the corridors over the decades. The colourful stained glass dome is spectacular, too.
As a museum, the Capitol Park Museum is better, telling multiple strands of Louisiana’s story. Other Baton Rouge attractions include the Magnolia Mound Plantation, built in 1791, and the environmentally educational Bluebonnet Swamp Nature Center.
More Houston road trips
- Getting to Houston: The best stops on the Abilene to Houston drive, Arlington to Houston drive, Dallas to Houston drive and Waco to Houston drive.
- Getting to Houston from interstate: The best stops on the Little Rock to Houston drive and Nashville to Houston drive.
- Texas road trips from Houston: The best stops on the Houston to Amarillo drive, Houston to Austin drive, Houston to Beaumont drive, Houston to Fort Worth drive and Houston to Lubbock drive.
- Interstate road trips from Houston: Where to stop on the Houston to Albuqueruque drive, Houston to Hot Springs AR drive, Houston to Memphis drive, Houston to Oklahoma City drive and Houston to Wichita drive.
- Heading east from Houston: Guides to the Houston to Baton Rouge drive and Houston to Lafayette drive.
